I.V FLUIDS:

Overview:

This stands for intravenous therapy i.e. "intra" means "within" and "venous" means "vein" ,also called electrolyte therapy because manage the electrolyte balance. These fluids are directly administrated in the circulatory system via a needle, given when someone's fluid volume falls e.g. in diarrhea, vomiting etc. fluids can be used as a route of medication administration. There are a number of ways to use it, some company provide packaged or some provide them mixed with sterile water (means that all the bacteria and viruses have been killed).

Types of I.V fluids:

1. Crystalloid:

Balanced salt/electrolyte solution; forms a true solution and is capable of passing     through   semi permeable membranes. May be isotonic, hypertonic, or hypotonic e.g. normal Saline (0.9% NaCl), Lactated Ringer's, Hypertonic saline (3, 5, & 7.5%), Ringer's solution.

1. Colloid:

High-molecular-weight solutions, draw fluid into intravascular compartment via oncotic pressure (pressure exerted by plasma proteins not capable of passing through membranes on capillary walls) e.g. lbumin, Hetastarch, Pentastarch (Pentaspan), Plasma, Dextran

1. Free H2O solutions:

Provide water that is not bound by macromolecules or organelles, free to pass through.D5W (5% dextrose in water), D10W, D20W, D50W, and Dextrose/crystalloid mixes

1. Blood products:

Whole blood, packed RBCs, FFP, cryoprecipitate, platelets, albumin. Essentially colloids.

          Commonly used I.V fluids are

 

• Lactated ringer's (LR)
• normal saline(NS),
• D5LR,
• D5NS,
• D5.45NS,
• D5.25NS,
• 7.5%NS,
• D5W,
• 6%hetastarch,
• 5% plasma protein(250 ml)

 

 

 

Methods of calculation of I.V fluids therapy

Can be calculated by three methods:

1. Holliday-Segar method.
2. Caloric method.
3. Body surface area method.

Guidelines for I.V fluids

• Intravenous Fluids are  liable to  Microbial Growth, contamination  of  Particulate  matter  leading  to  adverse  drug  reaction. 
• Careful handling to prevent damage from  cracks which  leads  to  contamination  of  fluids  meant  for  I.V administration.
• Precautions during temporary storage, transportation and handling.
• The applicant shall make adequate arrangements for the storage of drugs manufactured by him.
• Applicant shall, while applying for license to manufacture patent or proprietary medicines

Market Structure

World market growth is driven by population increases and constant up-scaling and sophistication of health care delivery. As part of this up-scaling, IV infusion therapy is becoming increasingly important in overall health care treatment regimens as new developments in antibiotics and other medications used in areas such as chemotherapy, burn centers, and renal/peritoneal dialysis centers favor intravenous use and application.

In emerging nations, where the cost of labor is much less and the cost of IV solutions often is much higher, the actual production cost figures can be 60% to 90% lower than market pricing. The market comprises almost 70% of the total world market for IV solutions, the market for third world total annual consumption = 18 billion 500ml units approx. The Production expectation at 5.4 million units annually meets approx. 2.5 hours consumption.

Beryl Drugs incorporated in 1993 is into manufacturing and marketing of branded, generic pharmaceutical formulations. The company is one of leading manufacturer of I.V.fluids in India and small volume injectables. Company owns brands like BERI-CEF injection, F-Neuron, Amplicillin INJ, P-Mol, Biprox, B-Flox and many more.

 These are some of the companies who are manufacturing IV fluids in India: Ahlcon Parenterals (India) Ltd, Biomed Hitech Inds Ltd,Gujarat Inject Ltd,Haffkine Bio-Pharmaceutical Corp  Ltd, Kokad Pharmaceutical Laboratories Ltd, Marck Biosciences Ltd, Parenteral Surgicals Ltd and Senbo Industries Ltd.

Orissa Drugs & Chemicals Ltd. (ODCL), a joint venture between Indian Drugs & Pharmaceuticals Ltd (IDPL) and Industrial Promotion and Investment Corporation of Orissa Limited (IPICOL), proposes to set up a IV Fluid (Intravenous fluids) manufacturing unit with an investment of Rs 60 crore. , the company has stepped up its production and clocked a turnover of Rs 11.65 crore in 2011-12 as against only Rs 33.82 lakh in 2004-05.

According to Financial Express Newspaper, intravenous fluids have a big market with an annual turnover of more than Rs 400 crore, which is growing at about 14% a year due to its essential nature. 80% of all patients admitted to a hospital as well as a similar number of patients in the emergency and intensive care units need intravenous fluids.

 NPCS can provide project consultancy services to any budding entrepreneur, who wants to manufacture IV fluids. Consultancy can provide the complete report covering topics like Plant Economics, Production Schedule, Land & Building, Site Development Expenses, and Working Capital Requirement etc. In order to get more information on how they can help you, please visit: http://goo.gl/mpnu8y

NPCS helps in establishing business prospective in preparation of adhesives. Detailed project report can be modified as per requirement of cost and capacity of the project. They have a state-of-the-art experience in preparing projects report on different subjects as per need.

You can also visit this website http://www.niir.org